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Bioactivation of foreign compounds

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Academic Press , Orlando
Xenobiotics -- Metabolism, Xenobiotics -- Physiological effect, Xenobiotics -- Toxicology, Biotransformation (Metabolism), Biotransformation, Drugs -- Metabolism, Biochem
Statementedited by M.W.Anders.
SeriesBiochemical pharmacology and toxicology
ContributionsAnders, M. W.
Classifications
LC ClassificationsQP529
The Physical Object
Paginationp. cm
ID Numbers
Open LibraryOL21119532M
ISBN 100120594803

Additional Physical Format: Online version: Bioactivation of foreign compounds.

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Orlando: Academic Press, (OCoLC) Document Type: Book. Bioactivation of Foreign Compounds (Biochemical Pharmacology and Toxicology Series): Medicine & Health Science Books @ Find many great new & used options and get the best deals for Bioactivation of Foreign Compounds (Biochemical Pharmacology and Toxicology Se.

at the best. The conjugation-dependent bioactivation of foreign compounds for carcinogenesis and toxicity had its origin in research. These investigations concerned primarily the metabolism and carcinogenicity of two compounds: 4-dimethylaminoazobenzene (DAB) and 2-acetylaminofluorene (AAF).

The carcinogenic activity of DAB in the rat has been first by: Purchase Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, Volume 27 - 1st Edition. Print Book & E-Book. ISBNThis book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications.

The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The emphasis is places on recent biomedical advances. Part of the Experientia Supplementum book series (EXS, volume 99) Abstract Bioactivation of Foreign Compounds.

Academic Press, New York Google Scholar. Dekant W.

Details Bioactivation of foreign compounds EPUB

() The role of biotransformation and bioactivation in toxicity. In: Luch A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol Cited by: As discussed before high amounts of bioactivation (toxic intermediates) can cause more damage than the original foreign toxic compound.

To protect the body against reactive intermediates we use: Conjugation reactions - make more water soluble. Glutathione - is an antioxidant and helps facilitate excretion (via bile/urine) Antioxidant enzymes. are essential for Bioactivation of foreign compounds book and detoxification of foreign compounds.

Many xenobiotics are non-toxic in nature; however, some of them become cytotoxic or carcinogenic after metabolic conversion. Reactive intermediates or metabolites generated during metabolic conversion are generally electrophilic in.

Pages ii-xvi, () Download full volume. Previous volume Show all chapter previews Show all chapter previews. Receive an update when the latest chapters in this book series are published. Sign in to set up alerts. select article Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.

Awards. - Merit Award, Society of Toxicology. - Symposium on "Bioactivation of Foreign Compounds Challenges for the Future." Held in honor of Professor Drag Anders.

The bioactivation of ticlopidine, a widely used antiplatelet drug, into reactive metabolites and their subsequent covalent binding to cellular macromolecules are thought to be involved in the Author: Deepak Dalvie. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Description Bioactivation of foreign compounds FB2

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in the metabolism of xenobiotics render this organ particularly susceptible to injury by chemicals to which we are ubiquitously exposed.

The pathogenesis of most chemical-induced liver injuries is. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related.

Keywords: foreign compounds, xenobiotics, bioactivation, detoxification, oxidation, cytochrome P, hydrolysis, conjugation, glucuronides, glutathione [Basic text book chapter on biotransformation, new editions appear with a few years intervals.] Vol.

II – Biotransformation of Xenobiotics and Hormones - File Size: KB. Springer, p. ISBN This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications.

The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and. Download Citation | Biotransformation: A Balance between Bioactivation and Detoxification | This chapter identified the fundamental principles of foreign compound (xenobiotic) modification by the.

Functional Medicine University’s Functional Diagnostic Medicine Training Program Module 6: FDMT A: The Physiology and Biochemistry of Biotransformation File Size: 2MB.

Title: Toxicological Profile for 2-Butanone Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at. Title: Toxicological Profile for 1,1-DICHLOROETHENE Subject of Planned Report: The ATSDR toxicological profile succinctly reviews the toxicologic, epidemiologic, and adverse health effects for the substance being also summarizes environmental fate and transport mechanisms and the potential for human exposure.

Purpose of Planned Report: The purpose of the toxicological profile. A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism.

It can also cover substances that are present in much higher concentrations than are usual. Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of. This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications.

The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspe. Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug.

Xenobiotica; the fate of foreign compounds in biological systems. 22() Harris JW, Jones JP, Martin JL, LaRosa AC, Olson MJ, Pohl LR, Anders MW. Bioactivation as a Basis for Chemical Toxicity. One of the possible results of the interaction of a xenobiotic with enzyme systems is the biotransformation of that compound to a chemically reactive intermediate (i.e.

Bioactivation). The reaction of either this initial reactive metabolite or. Author(s): Anders,M W(Marion Walter), Title(s): Bioactivation of foreign compounds/ edited by M.W. Anders. Country of Publication: United States Publisher.

This being the case it is a pity that the price is not lower to encourage the private buyer. ALDRIDGE Medical Research Council Toxicology Unit Carshalton, Surrey UK M. ANDERS (ed) Bioactivation of Foreign Compounds Biochemical Pharmacology and Toxicology Monographs, Academic Press Inc.

(Orlando, USA), ; pp. $ Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds Book Chapters Cytochrome P 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.

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Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds: Conjugation - Dependent Carcinogenicity and Toxicity of Foreign Compounds Vol 27 Advances in Pharmacology: Volume : M.

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Catecholic compounds belong to a heterogenous group of reactive molecules, but their reactivity is often determined by the catechol nucleus. In this overview, we have attempted to convey an appreciation of the complexity of the chemistry and biological behaviour of catecholic compounds.

Because catechols readily undergo oxidation to form Cited by: